A brief description of Provera:
Provera is a renowned medication that is commonly used in the treatment of secondary amenorrhea and abnormal uterine bleeding that is due to hormonal imbalance in the absence of organic pathologies, such as fibroids or uterine cancer. Provera possesses an active ingredient known as Medroxyprogesterone that is a type of female hormone (progestin). Medroxyprogesterone is also used to avert the overgrowth of the uterus lining in the postmenopausal women who is receiving estrogen hormone replacement therapy.
Mechanism of action of Provera:
Medroxyprogesterone has both androgenic and anabolic effects. Medroxyprogesterone shows its action mechanism by inhibiting the production of Gonadotropins, which causes follicular maturation and ovulation. It also decreases the frequency of Gonadotropin-releasing hormone released by the hypothalamus. It, therefore, makes the endometrium to become thin and atrophic and helps to treat certain menstrual problems.
The dosage regimen of Provera:
Commercially, Provera is available in a tablet dosage form with a dosing strength of 10 mg. For the treatment of secondary amenorrhea, Provera 10 mg should be given daily for 5 to 10 days. For the treatment of abnormal uterine bleeding, a dose of 5 or 10 mg of Provera should be given to the patient that should start from the 16th or 21st day of the menstrual cycle, daily for 10 days. Provera 10 mg tablet should be given for 12 to 14 consecutive days once in a month, to postmenopausal women who are already receiving 0.625 mg of conjugated estrogens daily, either commencement on the 1st day of the cycle or the 16th day of the cycle.
Contraindications of Provera:
- If you had ever experienced any kind of allergic or hypersensitivity reactions to Medroxyprogesterone or any other component present in Provera, then you should not take this medication.
- Do not take Provera if you are a pregnant woman, and should not be used in children.
Precautions while taking Provera:
- Do not drive or perform any other unsafe works that require special attention as it may cause dizziness.
- If you have, undiagnosed or unusual abnormal vaginal bleeding then you should avoid taking this medication.
- If you have a history of liver disease, kidney problem, heart attack, asthma, porphyria, mental disorders, and eye or vision problem, then you should not take this medication.
- If you have had a miscarriage, then you should avoid taking this medication.
Side effects of Provera:
Some common side effects of Provera include nausea, weight loss or gain, stomach cramps, vomiting, dizziness, sleeplessness, spotting or missed periods, and headache.