What are the therapeutic indications of Premarin?
Premarin is an excellent medication that provides relief from vaginal symptoms of menopause such as vaginal dryness, and burning or itching of the vagina and surrounding areas. It prevents osteoporosis in postmenopausal women and replaces the estrogen in women with ovarian failure. Sometimes, Premarin is also as part of cancer treatment in women and men such as prostate cancer and breast cancer. Premarin encloses a mixture of estrogens known as conjugated estrogens.
What is action mechanism of Premarin?
Women ovaries generate an essential hormone called Estrogen. Once the women reach their menopause, their body reduces the formation of estrogen and symptoms of menopause occur. Hence, Premarin works by providing locally acting estrogen and improve the drop of estrogen occurs in the body.
What is the dosing regimen of Premarin?
Premarin tablet is commercially obtainable in two dosing strengths of 0.3mg and 0.625mg. Dose recommended for the management of vaginal symptoms of menopause: Initially, a woman has to take 0.3mg of Premarin orally once a day with a colossal amount of water and the dose should be increased up to 0.625mg. It should be taken constantly for 25 days followed by 5 days off drug. Dose recommended for the management of hypogonadism, castration, or primary ovarian failure: A woman has to take 0.3 mg or 0.625 mg orally in a day for three consecutive weeks and one week off.
What are the contradictory conditions for the use of Premarin?
A person should not use Premarin if he or she is suffering from any of these medical conditions such as liver dysfunction, irregular vaginal bleeding, endometrial hyperplasia, any kind of breast, uterine, or hormone-reliant cancer, pregnancy, breastfeeding condition, and allergic reactions with Premarin or its other ingredients. A person with a history of heart attack, stroke, or blood clot should not use this medicine.
What are the precautions to be followed while using Premarin?
- Stay away from smoking or chewing tobacco while relying on the treatment of Premarin, otherwise, this may augment the risk of blood clots, stroke, or heart attack.
- Stay away from the direct contact to sunlight after the use of Premarin, so use protective clothing or sunscreen while going out in the sun.
- Patient relying on the treatment with thyroid medications must consult a doctor before using Premarin.
- Women with unusual vaginal bleeding should stay away from the use of Premarin tablet.
Are there any side effects of Premarin?
The common side effects are reported with the use of Premarin such as headache, queasiness, vomiting, bloating, stomach cramps, hair loss, breast pain or tenderness and vaginal itching or discharge.
Are there any drug interactions of Premarin?
Some medicines alter the therapeutic effectiveness of Premarin such as Anastrozole, Exemestane, Fulvestrant, Ospemifene, Raloxifene, Tamoxifen, Toremifene, and Tranexamic Acid.