What is Pregnyl 10000 IU?
Pregnyl, also known as human chorionic gonadotropins (HCG) is a wonderful medication used for treating infertility in women. Human chorionic gonadotropins (HCG) stimulates cells in the ovaries to produce progesterone. It is also used for the treatment of hypogonadism in males, to treat boys of age 4 to 9 years old who have testicles that have not moved into the scrotum.
What is the working mechanism of Pregnyl 10000 IU?
The mechanism of action of human chorionic gonadotropins (HCG) depends upon the purpose for which it is being used:
For treatment of infertility in women: In females with infertility, the Pregnyl has effects similar to the luteinizing hormone(LH), it promotes and develops the corpus luteum and produces progesterone, following Pregnyl administration maturation of oocytes occurs leading to ovulation.
For hypogonadism in males: In adult and adolescent men with hypogonadotropic hypogonadism, hCG acts like LH and stimulates testosterone production in the Leydig cells and spermatogenesis in the seminiferous tubules. Stimulation of androgen production by hCG causes development of secondary sex characteristics in males (e.g., deepening of voice, facial hair, etc.)
What is the Dosing regimen of Pregnyl?
The commonly administered dose of Pregnyl for the treatment of infertility is 5000-10000 IU units which contain 10,000 IU given in one day following last day of administration of menotropins. The Pregnyl is given through intramuscular route. For treating hypogonadism in males 500-1000 units is given 3 times a week for 3 weeks, followed by the same dose, which is given twice a week for another 3 weeks. Do not take more then recommended dose of Pregnyl.
Missed dose of Pregnyl:
In the case of a missed dose of Pregnyl, consult your doctor to reschedule your new dosing regimen.
What are the Contraindications of Pregnyl?
- Do not take Pregnyl if you are allergic to any ingredient present in the medication.
- Do not take Pregnyl if you have asthma, uterine fibroids, heart or kidney problems, migraine headaches, polycystic ovarian syndrome, or epilepsy.
- Do not take Pregnyl if you are pregnant.
What are the possible drug interactions of Pregnyl?
Do not take following classes of drugs such as:
- Drugs used for treating clotting disorders like coagulation factor IX and VII A
- Drugs increasing red blood cell production like Epoetin alpha.
- Anti-cancer drugs such as Avastin.
What are the possible side effects with the use of Pregnyl?
The possible side effects of Pregnyl are headache, irritability, nausea, fatigue, edema, precocious puberty, gynecomastia and pain at the site of injection.
What are the safety measures to be kept in mind while using Pregnyl?
- Do not consume alcohol with Pregnyl as it can cause dizziness.
- Do not drive or perform tasks which require alertness.
- It is advised to undergo a thorough gynecological examination before taking Pregnyl.
What are the ideal storage conditions for Pregnyl?
Store at the controlled room temperature at 15-30°C.Reconstituted solution is stable for
60 days when refrigerated.